Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice
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Rapid induction of intraneuronal neurofibrillary tangles in apolipoprotein E-deficient mice.
Cultured hippocampal slices prepared from apolipoprotein E-deficient mice were exposed to an inhibitor of cathepsins B and L and then processed for immunocytochemistry using antibodies against human paired helical filaments. Dense, AT8-immunopositive deposits were found in the subiculum, stratum oriens of hippocampal field CA1, and the hilus of the dentate gyrus. This distribution agrees with t...
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Deficient Mice − Deficient and Low-Density Lipoprotein Receptor − Apolipoprotein E Induction of Rapid Atherogenesis by Perivascular Carotid Collar Placement in Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2001 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/01.CIR...
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BACKGROUND Perivascular collar placement has been used as a means for localized atherosclerosis induction in a variety of experimental animal species. In mice, however, atherosclerosis-like lesions have thus far not been obtained by this method. The aim of this study was the development of a mouse model of rapid, site-controlled atherogenesis. METHODS AND RESULTS Silastic collars were placed ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2001
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.151253098